Ovarian Reserve is the medical term for " egg quality" (Please see the section of the web site for a more in depth discussion). The FSH level (from either a Baseline test (cycle day 2-5) or from a Clomiphene Challenge Test predicts outcomes. FSH is not a perfect predictor but it is the most common measure of egg quality.
In this table, we look at the Delivered/Ongoing Pregnancies based on everyone that starts an IVF cycle. We need to use outcomes per CYCLE START because women with decreased egg quality are more likely to get cancelled and never get to egg retrival or embryo transfer. Therefore if we only look at outcomes by embryo transfer then we will not fully appreciate the effect of the FSH level predicitng low fertility.
| 2005 to 2009 Pregnancy Success Rates | Age of Woman | ||||
| Fresh Embryos from Non-donor Eggs | <35 | 35-37 | 38-40 | 41-42 | >42 |
| Number of Cycles | 502 | 230 | 223 | 64 | 27 |
| Cancellations | 7% | 12% | 17% | 22% | 4% |
| Ongoing or Delivered pregnancies per Embryo Transfer | 64% | 48% | 37% | 24% | 17% |
| Multiple Gestation Rate | 45% | 35% | 30% | 7% | 0% |
| Frozen Embryos from Non-donor Eggs (NCRS only) | <35 | 35-37 | 38-40 | 41-42 | >42 |
| Number of Transfers | 66 | 33 | 16 | 2 | |
| Ongoing or Delivered pregnancies per Embryo Transfer | 55% | 48% | 42% | 0% | |
| Multiple Gestation Rate | 37% | 53% | 67% | 0% | |
The FSH groups are arbitrary but chosen to allow us to clinically categorize women's fertility. In an ideal situation (given enough patients in each category), we would provide outcome data for each value of FSH. We do not have enough patients to separate them that thinly. Notice that the success rates drop in each age group according to the level of FSH. Please also notice that the effect of the FSH level becomes more significant for women 41 and over. For women 41 years and older, almost any elevation of FSH indicates a serious problem. |
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| Ongoing or Delivered Pregnancies per Started Cycle | Age Groups |
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| Max FSH Level | <35 | 35-37 | 38-40 | 41-42 | >42 |
| < 12.0 | 62% | 47% | 35% | 27% | 22% |
| 12.0 - 16.9 | 55% | 38% | 24% | 8% | 0% |
| 17.0 - 20.9 | 48% | 31% | 20% | 0% | 0% |
| 21+ (very few patients in any age group) | 33% | 0% | 50% | 0% | 0% |
Prognosis Categories We know that not every patient has the same fertility potential. Many factors affect outcomes although no one has devised a clear cut scoring system. We attempted to deveop a clinical category system to better inform people of what their realistic chances for success might be. Obviously, FSH levels are one of the factors. We can clearly differentiate those couples who have a poor prognosis but the difference between GOOD and MEDIUM is less clear. |
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| Ongoing or Delivered Pregnancies per Embryo Transfer | Age of Woman | ||||
| Prognosis Group | <35 |
35-37 | 38-40 | 41-42 | >42 |
| Good | 68% | 52% | 42% | 38% | 44% |
| Medium | 62% | 56% | 41% | 38% | 0% |
| Poor | 46% | 28% | 29% | 15% | 0% |
| Donor Eggs | Fresh Transfer | Frozen Transfer* | |||
| Number of transfers | 148 | 67 | |||
| Ongoing or Delivered pregnancies per Embryo Transfer | 67% | 59% | |||
| Average number of embryos transferred | 2.1 | 1.8 | |||
| Multiple Gestation Rate | 45% | 43% | |||
*NCRS Cycles Only ; no previous PGD biopsy before freezing; plus NCRS embryos donated to other couplesFacts to note when reviewing clinic specific IVF statistics:
- A comparison of clinic success rates may not be meaningful because patient medical characteristics and treatment approaches may vary from clinic to clinic. – American Society for Reproductive Medicine
- These statistics are̓presented in a format very similar to that used by the Centers for Disease Control (CDC) and the Society for Assisted Reproductive Technology (SART) of the American Society for Reproductive Medicine (ASRM). Our first full year (2005) of completed data is available for viewing at the SART web site (http://www.sart.or/servlets/ listclinics?state=WA).
