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NCRS Egg Freezing Pioneers Boosted by New Research


Studies find frozen eggs as good as fresh for IVF—almost 90 percent thawed successfully—dispel doubts about vitrification process

SEATTLE, January 21, 2010 — Fertility specialists responsible for the first pregnancy in the Pacific Northwest resulting from frozen human eggs are hailing new research showing that frozen eggs can be as effective as fresh eggs in helping previously infertile women achieve pregnancy.

Among the new studies presented at the annual meeting of the American Society for Reproductive Medicine in October was one from Reproductive Biology Associates of Atlanta, finding that 85 percent of eggs survived thawing and that subsequent in vitro fertilization (IVF) of those eggs generated a 67-percent pregnancy rate—as good as the average success rate for fresh eggs. A second study from the New York University Fertility Center reported similar results in women who used frozen eggs to preserve fertility after cancer treatment. “Until recently, egg freezing was largely reserved for women undergoing cancer treatment who set aside their eggs in hopes of preserving post-recovery fertility options,” said Dr. Gerard Letterie of the Northwest Center for Reproductive Science (NCRS).

Letterie’s long-time research interests have included fertility preservation in cancer patients and as an elective option in patients who want to preserve fertility for non-medical reasons. The option was almost non-existent before 2004, and today NCRS is one of a small minority of fertility practices capable of egg freezing, thawing and fertilization.
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Managing Holiday Stress, Infertility, and Fizz

“The holidays, with their focus on the family, can be painful for couples dealing with in fertility,” says Gerard S Letterie, M.D., founder of Northwest Center for Reproductive Sciences.

“It is natural to reflect upon your hopes and dreams, losses and grief during the holidays. And if you belong to the imaginary club of ‘Couples Without Children,’ your pain may not be obvious to others,” he said.

“Infertility is a medical condition. It’s not all in your head. Our responses to this condition should to be as positive as possible particularly around the holidays,” he says. Research has shown that the stress associated with fertility treatment can be comparable to the stress associated with serious illness. More than 20 studies have shown that distress can cause or contribute to infertility, the duration of infertility, and indication for successful fertility treatment.
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Seattle woman achieves a milestone pregnancy

Northwest Center for Reproductive Sciences
For Immediate Release 

Seattle woman achieves a milestone frozen egg pregnancy and term delivery through her care at the Northwest Center for Reproductive Sciences. 

Northwest Center for Reproductive Sciences, one of the Pacific Northwest’s leading and most successful fertility centers is pleased to announce the region’s first delivery of a pregnancy resulting from frozen oocytes. This pregnancy resulted from the fertilization of oocytes (eggs) that were frozen using the latest technology in cryopreservation and the transfer of the resulting embryo into the mother. Though success using frozen oocytes has been infrequent, improvements in technology have better defined safe and effective techniques to freeze oocytes. “Once considered experimental” said Dr. Gerard Letterie, a reproductive endocrinologist at NCRS and the recipient of a grant to study oocyte freezing, “the techniques have improved over the past five years. With these improvements, they are ready for mainstream clinical care.” 
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Studies; Minor weight loss increases fertility

Two academic studies, one from England and a second from Australia confirm what researchers have long suspected; losing weight can make it easier for women to conceive.

Professor Bill Ledger from the University of Sheffield in England, said results indicated that obese women who lost a meager 5-10% of their weight increased blood flood in their bodies which in turn acted like a "switch" to activiate participants' ovaries. The three-month study of overweight women, many of whom were suffering from polycystic ovarian syndrome went on to conclude that even "minor" weight loss can increase a woman's chances of getting pregnant.
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View Dr. Letterie's KOMO 4 Interview

View Dr. Letterie's KOMO 4 Interview
 
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