Analysis of the semen is an essential test for all in fertility couples. About 40% of the time, male reproductive dysfunction is the primary cause of infertility. In another 35% of couples, a combination of male and female factors contribute to the infertile state. Consequently, it is imperative to identify semen disorders. The standard semen analysis evaluates the volume and consistency of semen, the number of sperm present in a given volume (concentration or “sperm count”), the percentage of sperm swimming as well as the quality of motion (motility and grade) and, finally, the shape of the sperm (“morphology”). When evaluated stringently, sperm morphology predicts fertility potential better than any other single characteristic. Currently, most infertility centers perform morphology analysis using very strict criteria for a “perfect or normal” sperm shape.